New tool may identify drugs for asthma, hypertension - (Business Standard via NewsPoints Desk)

  • According to a study published in Nature Biomedical Engineering, researchers have developed a tool that could facilitate the evaluation of new drugs for diseases associated with abnormal levels of cell strength, including hypertension, asthma and muscular dystrophy, reported Business Standard.

  • A key component of the device, dubbed fluorescently labeled elastomeric contractible surfaces (FLECS), is a flexible rectangular plate with more than 100 000 uniformly-spaced, X-shaped micropatterns of proteins that are sticky so cells settle on and attach to them.

  • To test the tool, investigators analysed drugs that make cells either contract or relax, using human smooth muscle cells that line airways in the body.

  • They compared the results of those tests to what was already known about how lung tissue reacts to the drugs and found that FLECS captured the same types of reactions, only more precisely because it could analyse the reactions in cell-by-cell detail.

  • "With this new tool, we can now test for potential therapeutics that can restore normal cellular force generation and therefore restore function to diseased tissues made of these cells," explained researcher Dino Di Carlo.

  • FirstWord Reports: Providing insight, analysis and expert opinion on important Pharma trends and challenging issues <Click here>

To read more NewsPoints articles, click here.

Reference Articles